INDICATIONS2

Hypothyroidism

EUTHYROX is indicated in pediatric and adult patients as a replacement therapy in primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired hypothyroidism.

Limitations of Use:

  • EUTHYROX is not indicated for suppression of benign thyroid nodules and nontoxic diffuse goiter in iodine-sufficient patients as there are no clinical benefits and overtreatment with EUTHYROX may induce hyperthyroidism.

World's most dispensed levothyroxine brand with more than 53 million patients treated1

EUTHYROX® (levothyroxine): Cost and Associated Factors

If you have an underactive thyroid (hypothyroidism), you might know about a medicine called levothyroxine. You might also know brand names like EUTHYROX® (levothyroxine sodium).

Levothyroxine is a medicine you can only get with a prescription. It helps people with hypothyroidism by giving them the thyroid hormone of which their body doesn't make enough. It can also be used to treat thyroid cancer and other thyroid problems.

Many factors can affect the prices for levothyroxine and EUTHYROX. Please read below for more details about what can influence your medication costs.

Factors Influencing Levothyroxine Cost

Brand-name vs. generic versions

Brand-name levothyroxine is more expensive than generic versions, but this is NOT the case with EUTHYROX® (levothyroxine sodium). EUTHYROX® is priced in line with generic versions of levothyroxine sodium and is generally covered as a Tier 1 copay or preferred brand on most insurances. If, for some reason, EUTHYROX® is not covered by insurance, the cash price should be less than $10 for a month’s supply at a retail pharmacy. Another option for cash-paying patients is to use the EUTHYROX® Direct program where your prescription can ship directly to your home, click here to learn more

Dosage strength variations

Higher doses or strengths of EUTHYROX® can be priced slightly higher than lower doses, as higher doses contain more active ingredient(s).

Prescription quantity (30-day vs. 90-day supply)

The duration of your prescription can also impact the cost of your levothyroxine. Generally, prescriptions with a longer duration can realize greater cost savings. To learn more about EUTHYROX® prices and cost-saving coupons, visit GoodRx and our pharmacy partners for EUTHYROX® Direct.

Pharmacy pricing policies

Even when manufacturers set their prices low, like with EUTHYROX®, pharmacies can add fees and additional charges. These are different from pharmacy to pharmacy and that can affect overall prices. Be sure to visit GoodRx and EUTHYROX® Direct to see some of the most competitive prices and coupons to help you save money.

Geographical location

Geography can impact distribution costs which can factor into the final price of medications. EUTHYROX® is priced in line with generic versions of levothyroxine sodium to keep prices low and pass savings along to the patient. Be sure to visit GoodRx and EUTHYROX® Direct to see some of the most competitive prices and coupons to help you save money.

Insurance coverage and formularies

Insurance coverage, benefit design, and formularies can impact drug prices as well. EUTHYROX® is priced low and is generally well covered by insurance, often with a Tier 1 copay. Depending upon your insurance, your Tier 1 copay could be higher than the cash price of EUTHYROX®. So, it’s always advised to ask your pharmacist for the cash price even when your medication is covered by insurance. EUTHYROX® is covered by most commercial insurance plans, Medicare, and Medicaid plans. Be sure to visit GoodRx and EUTHYROX® Direct to see some of the most competitive prices and coupons to help you save money.

Mail-order and online pharmacy options

Mail-order pharmacies, like the pharmacy partners who support EUTHYROX® Direct, act just like traditional retail pharmacies, but ship medications directly to your home. The process is simple. Your doctor will send your prescription to the mail-order or online pharmacy, you will set up your account with shipping and payment information, and the product will ship to your residence, usually in a few days. Be sure to visit EUTHYROX® Direct to learn more about our pharmacy partners and how this option may save you money on your medications.

Frequently asked questions about Levothyroxine Cost

How much does EUTHYROX® (levothyroxine sodium) cost with and without insurance?

Insurance coverage, benefit design, and formularies can impact drug prices as well. EUTHYROX® is priced low and is generally well covered by insurance, often with a Tier 1 copay. Depending upon your insurance, your Tier 1 copay could be higher than the cash price of EUTHYROX®. So, it’s always advised to ask your pharmacist for the cash price even when your medication is covered by insurance. EUTHYROX® is covered by most commercial insurance plans, Medicare, and Medicaid plans. Be sure to visit GoodRx and EUTHYROX® Direct to see some of the most competitive prices and coupons to help you save money.

Can you buy EUTHYROX® (levothyroxine sodium) over the counter?

A prescription for EUTHYROX® (levothyroxine sodium) must be prescribed by a health care provider. EUTHYROX can be filled at traditional retail pharmacies, mail-order, and/or online pharmacies. Be sure to visit GoodRx and EUTHYROX® Direct to see some of the most competitive prices and coupons to help you save money.

What’s the difference between brand name EUTHYROX® and generic levothyroxine?

Generic levothyroxine is manufactured by many companies. Brand name EUTHYROX® is produced by Merck KGaA, Darmstadt Germany, the largest producer of levothyroxine worldwide. Generic levothyroxine is usually priced far lower than brand-name levothyroxine, but NOT EUTHYROX®. EUTHYROX® is priced in line with generic versions of levothyroxine sodium to offer patients a branded option at an affordable price, often 5-10 times lower than other branded cash pay prices.

Provision of generic levothyroxine can result in patients being switched from manufacturer to manufacturer. You may have experienced this yourself if you’ve ever seen your tablets change shape or color from one refill to the next. Although your prescription and dose or strength may not have changed, it’s likely that the manufacturer your pharmacy purchases from has changed. This type of switching across levothyroxine manufacturers is a concern and the joint statement below provides guidance from top professional societies in thyroid care:

American Association of Clinical Endocrinologists (AACE), The Endocrine Society (TES), and American Thyroid Association (ATA) Joint Position Statement on the Use and Interchangeability of Thyroxine Products

Best Patient Practices:

Use the same brand of thyroid medication throughout your treatment. Thyroid disease often requires lifelong therapy and is best managed with consistent and precise treatment with the same brand of thyroid hormone. Your doctor may change your dose of thyroid hormone, but the brand of your thyroid hormone medication should always stay the same.

When you go to the pharmacy, do not change the brand of your thyroid medication without checking with your doctor. You should not change from one brand of thyroid medication to another, from your brand of thyroid medication to a generic product, or from one generic product to another without first checking with your doctor. Repeat blood tests and visits to your doctor may be required, and your dose may need to be readjusted if your thyroid medication is changed, or if you switch to a generic product.*

If you have concerns about EUTHYROX® or your levothyroxine being switched, please consult your healthcare provider.

* https://www.thyroid.org/thyroxine-products-joint-position-statement/ Accessed AUG 2024

INDICATIONS2

Hypothyroidism

EUTHYROX is indicated in pediatric and adult patients as a replacement therapy in primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired hypothyroidism.

Pituitary Thyrotropin (Thyroid Stimulating Hormone, TSH) Suppression

EUTHYROX is indicated in pediatric and adult patients as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer.

Limitations of Use:

  • EUTHYROX is not indicated for suppression of benign thyroid nodules and nontoxic diffuse goiter in iodine-sufficient patients as there are no clinical benefits and overtreatment with EUTHYROX may induce hyperthyroidism.
  • EUTHYROX is not indicated for treatment of hypothyroidism during the recovery phase of subacute thyroiditis.

IMPORTANT SAFETY INFORMATION2

WARNING: NOT FOR TREATMENT OF OBESITY OR FOR WEIGHT LOSS
Thyroid hormones, including EUTHYROX, either alone or with other therapeutic agents, should not be used for the treatment of obesity or for weight loss. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects.

CONTRAINDICATIONS

EUTHYROX is contraindicated in patients with uncorrected adrenal insufficiency.

WARNINGS AND PRECAUTIONS

  • EUTHYROX has a narrow therapeutic index. Overtreatment or undertreatment with EUTHYROX may have negative effects on growth and development, cardiovascular function, bone metabolism, reproductive function, cognitive function, emotional state, gastrointestinal function, and glucose and lipid metabolism in adult or pediatric patients. Titrate the dose of EUTHYROX carefully and monitor response to titration to avoid these effects. Monitor for the presence of drug or food interactions when using EUTHYROX and adjust the dose as necessary.
  • In the elderly and in patients with cardiovascular disease, initiate EUTHYROX at lower doses than those recommended in younger individuals or in patients without cardiac disease.
  • Patients with coronary artery disease who are receiving EUTHYROX should be monitored closely during surgical procedures for cardiac arrythmias. Monitor patients during concomitant administration of EUTHYROX and sympathomimetic agents for signs and symptoms of coronary insufficiency. If cardiovascular symptoms develop or worsen, reduce or withhold the EUTHYROX dose for one week and restart at a lower dose.
  • Use of oral thyroid hormone is not recommended to treat myxedema coma. Use products formulated for IV administration to treat myxedema coma.
  • Treat patients with adrenal insufficiency with replacement glucocorticoids prior to initiating treatment with EUTHYROX. Failure to do so may precipitate an acute adrenal crisis when thyroid hormone therapy is initiated.
  • Addition of levothyroxine therapy in patients with diabetes mellitus may worsen glycemic control and result in increased antidiabetic agent or insulin requirements. Carefully monitor glycemic control after starting, changing, or discontinuing EUTHYROX.
  • Increased bone resorption and decreased bone mineral density may occur as a result of levothyroxine over-replacement, particularly in postmenopausal women. To mitigate this risk, administer the minimum dose of EUTHYROX that achieves the desired response.

ADVERSE REACTIONS

  • Adverse reactions associated with EUTHYROX therapy are primarily those of hyperthyroidism due to therapeutic overdosage: arrhythmias, myocardial infarction, dyspnea, muscle spasm, headache, nervousness, irritability, insomnia, tremors, muscle weakness, increased appetite, weight loss, diarrhea, heat intolerance, menstrual irregularities, and skin rash.
  • In pediatric patients receiving levothyroxine therapy, pseudotumor cerebri and slipped capital femoral epiphysis have been reported. Overtreatment may result in craniosynostosis in infants and premature closure of the epiphyses in pediatric patients with resultant compromised adult height.
  • Seizures have been reported rarely with levothyroxine therapy.

DRUG INTERACTIONS

  • Many drugs and some foods affect thyroid hormone pharmacokinetics and metabolism and may alter the therapeutic response to EUTHYROX. In addition, thyroid hormones and thyroid status have varied effects on the pharmacokinetics and actions of other drugs. Administer at least 4 hours before or after drugs that are known to interfere with absorption. Evaluate the need for dose adjustment when regularly administering within one hour of certain foods that may affect absorption. Prescribers should consult appropriate reference sources for additional information on drug or food interactions with EUTHYROX.

USE IN SPECIFIC POPULATIONS

  • EUTHYROX should not be discontinued during pregnancy, and hypothyroidism diagnosed during pregnancy should be promptly treated. TSH levels may increase during pregnancy, so TSH should be monitored and EUTHYROX dose adjusted as needed.

PLEASE REFER TO THE FULL PRESCRIBING INFORMATION THAT CAN BE FOUND HERE.

This is the most important safety information you should know about EUTHYROX. For more information, talk with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. You can do this by contacting FDA at 1-800-FDA-1088 or you can visit www.fda.gov/medwatch.

To contact us regarding a product quality issue or submit a medical inquiry, click here.

Tell your healthcare provider if you experience any of the following: fast or irregular heartbeat, chest pain, shortness of breath, leg cramps, headache, nervousness, irritability, sleeplessness, tremors, change in appetite, weight gain or loss, vomiting, diarrhea, excessive sweating, heat intolerance, fever, changes in menstrual period, hives or skin rash, or any other unusual medical event.

These are not all the possible side effects of EUTHYROX. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

EUTHYROX® is a registered trademark of Merck KGaA Darmstadt, Germany.

USP: The US Pharmacopeia is a reference of uniform preparations for the most commonly used drugs—with tests to ensure their quality, potency and purity.